Endocrine Abstracts

Introduction: Patients with multiple sclerosis (MS) demonstrate, in a number of studies, increased risk of acquiring another autoimmune disease compared to general population. Autoimmune thyroid diseases, type 1 diabetes, psoriasis and inflammatory bowel disease are the most common reported. The aim of our study is to determine potential factors that affect the presence of autoimmune endocrinopathies in patient with relapsing and remitting MS.Methods: We...

Introduction: Only few studies were observed, supporting the hypothesis that the administration of high doses of vitamin E in people with elevated serum total cholesterol levels leads to increased adrenocortical hormone secretion. There are only limited data concerning androgen or estrogen levels. The aim of this study is to investigate the possible effect of Vitamin E on adrenal and sex hormones in rabbits with hypercholesterolemia, as an animal model for the research.<p ...

Introduction: Patients with Graves’ disease (GD) and thyroid nodules have an elevated risk of developing papillary thyroid carcinoma (PTC). Distant metastasis observed in 1-9% of patients with PTC. The classical subtype usually demonstrates favorable prognosis compared to other more aggressive PTC subtypes, for which an increased risk of extranodal metastases is observed.Aim of the Study: We present an unusual case of a young male diagnosed with cla...

Case history: Herein, we report the case of a 79-year-old male who presented acutely to A&E with recurrent episodes of symptomatic hypoglycaemia. A random glucose at presentation was low at 1.4 mmol/l and upon correction symptoms resolved. While hospitalized, he continued having episodes of symptomatic hypoglycaemia, requiring treatment with intravenous dextrose and per os steroids. Once stable, he was discharged with advice.Investigations: ...

Objective: Quality of life is currently considered a major factor in the assessment of disease outcome. The aim was to assess quality of life in acromegaly and the effect of somatostatin analogues on it.Design: This study included 101 patients with acromegaly, mean age 59.51±1.35 years (mean ± S.E.M.), with a disease duration of 12.88±0.96 years. All subjects completed the Acromegaly Quality of Life Questionnaire (AcroQoL) w...

Introduction: Thyroid autoimmunity and diabetes mellitus type 2 (DM2) are the commonest endocrine disorders in the general population. The aim of the study was to investigate whether there is an association between thyroid autoimmunity and β-cell secretion in patients with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT).Methods/design: 501 patients (381 females) 46.5±14.2 years with IFG and/or IGT and autoimmune thyroidit...

Introduction: Neuroendocrine neoplasms (NENs) are rare and heterogeneous neoplasms with variable biological behaviour but generally slow progression.Methods/design: 355 patients with NENs registered in our data-base have been studied (166 females, mean age: 52 years; range: 11–88), during the period 2004–2014. TNM system has been used for staging and proliferation index Ki-67 for grading.Results: Out of 355 patients, 35 (...

Introduction: ACTH-secreting pituitary carcinomas are rare neoplasms but there are not factors till now to predict their aggressive evolution nor a standard practice to their management.Case report: We report a 43-year-old female patient presented in 1990 with Cushing’s syndrome due to ACTH-secreting pituitary microadenoma who had been submitted on trans-sphenoidal surgery with cure as defined by post-operative cortisol serum levels <50 nmol/l. ...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a genetic disorder involving mainly parathyroid tumours, pancreatic neuroendocrine neoplasms (pNENs) and pituitary tumours. In the present study we have registered demographic, clinical, imaging, pathological characteristics, therapeutic options, response to treatment and overall outcome of patients with MEN1.Methods/design: 35 patients with MEN1 registered in our data base have been studied (14...

Background: Subclinical Cushing’s syndrome (SCS) due to incidentally discovered adrenal adenomas (AI) has been associated with increased prevalence of hypertension, obesity, and impaired glucose tolerance which are established risk factors for cardiovascular morbidity. Although functional and morphological (structural) changes of endothelium have been correlated with cardiovascular morbidity this has not been looked into detail in patients with adrenal incidentalomas....